PET/CT, however, is time-consuming, cost-extensive, linked to high radiation and has a low availability. B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Med. Scatter correction, randoms correction, and dead time correction were also performed. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). [Initial treatment strategy for classical Hodgkin lymphoma in adults]. 3: 445. All articles published by MDPI are made immediately available worldwide under an open access license. Clipboard, Search History, and several other advanced features are temporarily unavailable. WebA case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review Jew Win Kuan 1, Noraidah Masir 2 1 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia 2 Prince Court Medical Centre, Pantai Premier Pathology, Kuala There were 15 datasets per patient (scanner A: 10 patients with 1 scan, 11 patients with 2 scans, 3 patients with 3 scans, 2 patients with 5 scans and scanner B: 11 patients with 1 scan, 5 patients with 2 scans, 1 patient with 3 scans). Web Close. doi: 10.1002/14651858.CD007941.pub3. Concordance was defined as agreement between the DS assigned and the line of treatment. https://doi.org/10.1080/10428194.2020.1786555 (2020). Psychol. 3D Slicer as an image computing platform for the Quantitative Imaging Network. Article HL is often curable by conventional chemotherapy and radiotherapy. Patients were classified as true positive at follow-up if they had evidence of disease at interim imaging, followed by persistent disease and/or evidence of recurrence at the end of therapy. The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. For patients with high total metabolic tumor volume, the 2-year PFS rate was 90.9% (95% CI, 74.4 to 97.0) and 70.7% (95% CI, 39.4% to 87.9%) in the BV-AVD and ABVD arms, respectively. Clin. EJNMMI Phys 7, 2. https://doi.org/10.1186/s40658-020-0270-y (2020). ; Amthauer, H.; Mller, H.W. Epub 2022 Jul 25. Furth, C.; Steffen, I.G. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. 77, e104e107. N Engl J Med. Interv. (ac) A 20-year-old female patient with the initial diagnosis of Hodgkins lymphoma. Webfor Pediatric Hodgkin Lymphoma? Northwestern University, Evanston, Illinois. This articledid not receive any funding. government site. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. ; data curation, F.I. the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, Med. Harell, F. Jr. Hmisc: Harrell Miscellaneous. Cancer Res. Radiomic features. However, SUVmax did not predict the survival outcome using 59.8% of the optimal cutoff value. Disclaimer. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. Avigdor A, Bulvik S, Levi I, Dann EJ, Shemtov N, Perez-Avraham G. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A. Ann Hematol. Radiol. Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H. Barrington SF, Qian W, Somer EJ, Franceschetto A, Bagni B, Brun E. Itti E, Meignan M, Berriolo-Riedinger A, Biggi A, Cashen AF, Vra P. Cheson BD, Ansell S, Schwartz L, Gordon LI, Advani R, Jacene HA. Copyright 2023 American Academy of Family Physicians. Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. No special See further details. ; Hudson, M.M. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. articles published under an open access Creative Common CC BY license, any part of the article may be reused without Details of the patients are summarized in Table 1. Save my name, email, and website in this browser for the next time I comment. The site is secure. ; Unal, S.N. The study was conducted in accordance with the Declaration of Helsinki. The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies. However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. official website and that any information you provide is encrypted Article Open Access funding enabled and organized by Projekt DEAL. Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Ills , Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group. Swerdlow, A.J. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. EJNMMI Phys. 120, 7924 (2020). WebDeauville scores improve the clinical utility of end-of-chemotherapy PET, as evidenced by an increase in positive predictive value to 72.7% from 44.4% on the basis of report alone. Cite this article. Kwee TC, Kwee RM, Nievelstein RA. Would you like email updates of new search results? Rep. 10, 11649. https://doi.org/10.1038/s41598-020-68310-w (2020). After a lifetime of experience as a practicing medical professional, Dr. Stephen Cohen has created a repository of insightful medical information. Bull. https://doi.org/10.1016/j.mri.2012.05.001 (2012). Results: WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. 18F-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is the standard diagnostic test for end-of-treatment assessment in Hodgkin lymphoma1, which accounts for 10% of all diagnosed lymphomas2. Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. ; resources, F.I., A.R.V. Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy.24 Radiotherapy alone is not recommended.25 Toxicity from radiotherapy can lead to serious long-term complications such as secondary cancers in the irradiated area, including breast or lung cancers.25 Additionally, patients receiving chemotherapy can subsequently develop breast or lung cancers, melanoma, or acute myeloid leukemia.26,27 Patients who are older than 60 years at diagnosis have worse outcomes, regardless of the staging. pROC: An open-source package for R and S+ to analyze and compare ROC curves. Children and adolescents with newly diagnosed stage IA, IB, and IIA classical Hodgkin lymphoma younger than 18 years of age were assigned to treatment group 1 to be treated with two A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score. and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma, Patients should follow up with an oncologist every three to six months for the first two years. 1996-2023 MDPI (Basel, Switzerland) unless otherwise stated. PubMed Central Leuk Lymphoma 2009;50:1257-60. Julie Faudemer, Nicolas Aide, Charline Lasnon, Queralt Martn-Saladich, Gabriel Reyns-Llompart, Montse Corts-Romera, Sarah A. Milgrom, Hesham Elhalawani, Grace L. Smith, Jeong Rye Kim, Hee Mang Yoon, Jin Seong Lee, Maria E. S. Takahashi, Camila Mosci, Celso D. Ramos, Amandine Cromb, Michle Kind, Olivier Saut, Lea Azour, Jane P. Ko, William H. Moore. 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